JH-II-127

• Catalog number
  9632-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone
• Description
  JH-II-127 is a highly potent, selective, and cell-permeable LRRK2 inhibitor, with IC₅₀ of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.
• CAS Number
  1700693-08-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₁ClN₆O₃
• Molecular Weight
  416.87
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A highly potent, selective, and cell-permeable LRRK2 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• SMILES
  O=C(C1=CC=C(NC2=NC(NC)=C3C(NC=C3Cl)=N2)C(OC)=C1)N4CCOCC4
• InChi
  InChI=1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)
• InChi Key
  HUEKBQXFNHWTQQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  JH-II-127  
• Gene symbol
  YPEL5, MIR127, PATE3, RNVU1-17, CRABP2, SPINK2, MGST2, IBSP, HJV, APOL2
• Short name
  JH-II-127
• Alternative name
  JH-II-127

Gene info

• Identity
  HGNC:18329
• Gene
  YPEL5
• Long gene name
  yippee like 5
• Synonyms gene name
  • yippee-like 5 (Drosophila)
• Synonyms
  • CGI-127
• GenBank acession
  • AF135161
• Locus
  2p23.1
• Discovery year
  2004-06-28
• Entrez gene record
  51646
• Pubmed identfication
  • 15556292
• RefSeq identity
  • NM_016061
• Classification
  • Yippee like family
• VEGA ID
  OTTHUMG00000097839

Gene info

• Identity
  HGNC:31509
• Gene
  MIR127
• Long gene name
  microRNA 127
• Synonyms gene
  • MIRN127
• Synonyms
  • hsa-mir-127
• Locus
  14q32.2
• Discovery year
  2004-04-23
• Entrez gene record
  406914
• Pubmed identfication
  • 16766263
• RefSeq identity
  • NR_029696
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:35426
• Gene
  PATE3
• Long gene name
  prostate and testis expressed 3
• Synonyms
  • PATE-DJ
  • HEL-127
• GenBank acession
  • EF426753
• Locus
  11q24.2
• Discovery year
  2008-12-17
• Entrez gene record
  100169851
• Pubmed identfication
  • 18390568
• RefSeq identity
  • NM_001129883
• Classification
  • PATE family
  • LY6/PLAUR domain containing
• VEGA ID
  OTTHUMG00000165857

Gene info

• Identity
  HGNC:48322
• Gene
  RNVU1-17
• Long gene name
  RNA, variant U1 small nuclear 17
• Synonyms
  • vU1.17
  • RNU1-127
• Locus
  1q21.2
• Discovery year
  2013-04-25
• Entrez gene record
  101954269
• Pubmed identfication
  • 23070852
• RefSeq identity
  • NR_104078
• Classification
  • Variant U1 small nuclear RNAs

Gene info

• Identity
  HGNC:2339
• Gene
  CRABP2
• Long gene name
  cellular retinoic acid binding protein 2
• Synonyms gene name
  • cellular retinoic acid-binding protein 2
• Synonyms
  • CRABP-II
• GenBank acession
  • BC001109
• Locus
  1q23.1
• Discovery year
  1992-11-25
• Entrez gene record
  1382
• Pubmed identfication
  • 1654334
• RefSeq identity
  • NM_001878
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000041300

Gene info

• Identity
  HGNC:11245
• Gene
  SPINK2
• Long gene name
  serine peptidase inhibitor Kazal type 2
• Synonyms gene name
  • serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
• Synonyms
  • HUSI-II
• Synonyms name
  • acrosin-trypsin inhibitor
• GenBank acession
  • BC022514
• Locus
  4q12
• Discovery year
  1993-12-01
• Entrez gene record
  6691
• Pubmed identfication
  • 8428671
• RefSeq identity
  • NM_021114
• Classification
  • Serine peptidase inhibitors, Kazal type
• VEGA ID
  OTTHUMG00000128769

Gene info

• Identity
  HGNC:7063
• Gene
  MGST2
• Long gene name
  microsomal glutathione S-transferase 2
• Synonyms
  • MGST-II
• GenBank acession
  • U77604
• Locus
  4q31.1
• Discovery year
  1997-10-16
• Entrez gene record
  4258
• Pubmed identfication
  • 8703034
• RefSeq identity
  • NM_002413
• Classification
  • Microsomal glutathione S-transferases
• VEGA ID
  OTTHUMG00000133382

Gene info

• Identity
  HGNC:5341
• Gene
  IBSP
• Long gene name
  integrin binding sialoprotein
• Synonyms
  • BSP
  • SP-II
  • BSP-II
• Synonyms name
  • bone sialoprotein
  • bone sialoprotein II
• Locus
  4q22.1
• Discovery year
  1993-03-23
• Entrez gene record
  3381
• Pubmed identfication
  • 8406493
• Classification
  • SIBLING family
• VEGA ID
  OTTHUMG00000130600

Gene info

• Identity
  HGNC:4887
• Gene
  HJV
• Long gene name
  hemojuvelin BMP co-receptor
• Synonyms gene
  • HFE2
• Synonyms gene name
  • hemochromatosis type 2 (juvenile)
• Synonyms
  • JH
  • HFE2A
  • RGMC
  • hemojuvelin
  • haemojuvelin
• Synonyms name
  • repulsive guidance molecule c
• GenBank acession
  • AY372521
• Locus
  1q21.1
• Discovery year
  1999-05-25
• Entrez gene record
  148738
• Pubmed identfication
  • 10205270
  • 14647275
• RefSeq identity
  • NM_145277
• Classification
  • Repulsive guidance molecule family
• VEGA ID
  OTTHUMG00000013748

Gene info

• Identity
  HGNC:619
• Gene
  APOL2
• Long gene name
  apolipoprotein L2
• Synonyms
  • APOL-II
• Synonyms name
  • apolipoprotein L-II
• GenBank acession
  • AF324224
• Locus
  22q12.3
• Discovery year
  1999-10-29
• Entrez gene record
  23780
• Pubmed identfication
  • 10591208
  • 11374903
• RefSeq identity
  • NM_145637
• Classification
  • Apolipoproteins
• VEGA ID
  OTTHUMG00000150634

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