Itraconazole

• Catalog number
  1987-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  (2R,4S)-rel-1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one; Oriconazole, R51211, Sporanox
• Description
  A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that Itraconazole inhibits Hedgehog (Hh) signaling pathway activity (IC50 = 0.8 µM) as well as blocks the VEGFR2 glycosylation, trafficking, and signaling in endothelial cells.
• CAS Number
  84625-61-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₅H₃₈Cl₂N₈O₄
• Molecular Weight
  705.63
• Cell Permeable
  No
• Purity
  ≥97%
• Solubilities
  DMSO
• Handling
  Protect from light and air
• Tag Line
  An antifungal agent and Hh signaling inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  60 months
• MDL Number
  MFCD00870168
• PubChem CID
  6917738
• PubChem CID Link
• SMILES
  CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
• InChi
  InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3, 14-17,19-21H2,1-2H3/t25?,31-,35-/m1/s1
• InChi Key
  VHVPQPYKVGDNFY-AVQIMAJZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Itraconazole  
• Short name
  Itraconazole
• Alternative name
  Itraconazole

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