IDO1 Inhibitor I

• Catalog number
  2745-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
• Description
  IDO1 Inhibitor I is a potent IDO1 inhibitor that displays IC₅₀ values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively. It is inactive against tryptophan 2,3-dioxygenase (IC₅₀ > 10 µM).
• CAS Number
  914471-09-3
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₉H₇ClFN₅O₂
• Molecular Weight
  271.63
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent indoleamine 2,3-dioxygenase (IDO1) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  53434622
• PubChem CID Link
• SMILES
  C1=CC(=C(C=C1NC(=C2C(=NON2)N)N=O)Cl)F
• InChi
  InChI=1S/C9H7ClFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,13,15H,(H2,12,16)
• InChi Key
  MUVQOOPKPBEAJZ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  IDO1   Inhibitor  
• Gene symbol
  IDO1
• Short name
  IDO1 Inhibitor I
• Alternative name
  indoleamine 2,3-dioxygenase 1 suppressor I
• Alternative to gene target
  indoleamine 2,3-dioxygenase 1, IDO and IDO-1 and INDO, IDO1 and IDBG-18750 and ENSG00000131203 and 3620, tryptophan 2, Cytoplasm, Ido1 and IDBG-142448 and ENSMUSG00000031551 and 15930, BT.19792 and IDBG-629572 and ENSBTAG00000020602 and 506281

Gene info

• Identity
  HGNC:6059
• Gene
  IDO1
• Long gene name
  indoleamine 2,3-dioxygenase 1
• Synonyms gene
  • IDO
  • INDO
• Synonyms gene name
  • indoleamine-pyrrole 2,3 dioxygenase
• GenBank acession
  • M34455
• Locus
  8p11.21
• Discovery year
  1993-05-26
• Entrez gene record
  3620
• Pubmed identfication
  • 2109605
  • 8404046
• RefSeq identity
  • NM_002164
• VEGA ID
  OTTHUMG00000164057

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