ICG-001

• Catalog number
  2275-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (6S,9aS)-Hexahydro-6-[(4-hydroxyphe­nyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(­phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-c­arboxamide
• Description
  A specific inhibitor of Wnt/β-catenin signaling pathway. It down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein (CBP). ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
• CAS Number
  847591-62-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₃H₃₂N₄O₄
• Molecular Weight
  548.63
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~50 mg/ml) or EtOH (~25 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A specific inhibitor of Wnt/β-catenin signaling pathway
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  11238147
• PubChem CID Link
• SMILES
  C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
• InChi
  InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s1
• InChi Key
  HQWTUOLCGKIECB-XZWHSSHBSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ICG-001  
• Gene symbol
  MTCO1P5, LINC01537, ATP2C2-AS1, OR3A5P, GCASPC
• Short name
  ICG-001
• Alternative name
  ICG-001

Gene info

• Identity
  HGNC:51300
• Gene
  MTCO1P5
• Long gene name
  MT-CO1 pseudogene 5
• Synonyms gene name
  • mitochondrially encoded cytochrome c oxidase I pseudogene 5
• Synonyms
  • AC026166.2-001
• Locus
  3p25.2
• Discovery year
  2014-09-25
• Pubmed identfication
  • 25243407
• VEGA ID
  OTTHUMG00000155369

Gene info

• Identity
  HGNC:51301
• Gene
  LINC01537
• Long gene name
  long intergenic non-protein coding RNA 1537
• Synonyms
  • RP11-169D4.1-001
• GenBank acession
  • AL832797
• Locus
  11q13.4
• Discovery year
  2014-09-25
• Entrez gene record
  101928555
• Pubmed identfication
  • 25243407
  • 31374807
• Classification
  • Long intergenic non-protein coding RNAs
• VEGA ID
  OTTHUMG00000167927

Gene info

• Identity
  HGNC:53167
• Gene
  ATP2C2-AS1
• Long gene name
  ATP2C2 antisense RNA 1
• Synonyms
  • RP11-517C16.2-001
  • RP11-517C16.2
• Locus
  16q24.1
• Discovery year
  2017-03-10
• Entrez gene record
  105371374
• Pubmed identfication
  • 28265570
  • 29712923
• RefSeq identity
  • NR_146503
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:8286
• Gene
  OR3A5P
• Long gene name
  olfactory receptor family 3 subfamily A member 5 pseudogene
• Synonyms gene name
  • olfactory receptor, family 3, subfamily A, member 5 pseudogene
• Synonyms
  • OLFRA06
  • OR25
  • OR17-25
  • RP11-64J4.6-001
• GenBank acession
  • AF087921
• Locus
  17p13.3
• Discovery year
  1998-01-29
• Entrez gene record
  100856809
• Pubmed identfication
  • 8921386
• Classification
  • Olfactory receptors, family 3
• VEGA ID
  OTTHUMG00000185967

Gene info

• Identity
  HGNC:52281
• Gene
  GCASPC
• Long gene name
  gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA
• Synonyms
  • TCONS_00011605
  • RP1-56L9.7-001
  • lnc-SOD2-1
• Locus
  6q25.3
• Discovery year
  2016-08-04
• Entrez gene record
  112441427
• Pubmed identfication
  • 27450454
• Classification
  • Long non-coding RNAs with non-systematic symbols

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