Human CellExp™ HDAC5, Catalytic Domain, Human Recombinant, Active

• Catalog number
  P1268-50
• Price
  Please ask
• Size
  50 ug

• Synonyms
  HDAC5, HD5, Histone Deacetylase 5
• Alternative_names
  HDAC5, HD5, Histone Deacetylase 5, Antigen NY-CO-9, KIAA0600
• Description
  Key epigenetic regulator
• Recombinant
  Yes
• Source
  HEK293 cells
• Purity by SDS PAGE
  ≥95%
• Assay
  SEC
• Activity Specifications test method
  Deacetylation activity was determined using the Boc-K(TFA)-AMC substrate.
• Molecular Weight
  45 kDa
• Storage Temp
  -80°C
• Shipping
  Dry Ice
• Shelf Life
  12 months
• Appearance
  Liquid
• Physical form description
  In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.6
• Background Information
  Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence. Both domains are required for HDAC5- mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.
• Handling
  Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   HDAC5   Catalytic   Domain   Active  
• Gene symbol
  HDAC5
• Short name
  CellExp™ HDAC5, Catalytic Domain, Recombinant, Active
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ histone deacetylase 5, Catalytic Domain, H. sapiens Rec., functionnal
• Alternative technique
  rec
• Alternative to gene target
  histone deacetylase 5, HD5 and NY-CO-9, HDAC5 and IDBG-53295 and ENSG00000108840 and 10014, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, Hdac5 and IDBG-212520 and ENSMUSG00000008855 and 15184, HDAC5 and IDBG-640847 and ENSBTAG00000016254 and 504242

Gene info

• Identity
  HGNC:14068
• Gene
  HDAC5
• Long gene name
  histone deacetylase 5
• Synonyms
  • KIAA0600
  • NY-CO-9
  • FLJ90614
• GenBank acession
  • AF249731
• Locus
  17q21.31
• Discovery year
  2000-11-28
• Entrez gene record
  10014
• Pubmed identfication
  • 10220385
  • 9610721
• RefSeq identity
  • NM_001015053
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000181806

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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