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Alternative_name
N-hydroxy-4-[2-[N-(2-hydroxyethyl)anilino]-2-oxoethyl]benzamide; 4-[2-[2-Hydroxyethyl(Phenyl)amino]-2-Oxidanylidene-Ethyl]-~{n}-Oxidanyl-Benzamide; 4-[(Hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenylbenzeneacetamide
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Description
HPOB is a hydroxamic acid-based small-molecule that selectively inhibits histone deacetylase 6 (HDAC6). The IC₅₀ for inhibition of recombinant HDAC6 is 56 nM. It inhibits the growth of normal human foreskin fibroblast (HFS) and transformed (LNCaP, human prostate adenocarcinoma, A549 lung adenocarcinoma, and U87 glioblastoma) cells in a concentration-dependent manner at 8 μM, 16 μM, or 32 μM, but does not induce cell death. HPOB causes accumulation of acetylated α-tubulin in these cells. HPOB enhances cell death induced by the anticancer drugs etoposide, doxorubicin and SAHA.
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CAS Number
1429651-50-2
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Structure Available
True
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Salt Form
False
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Molecular Formula
C₁₇H₁₈N₂O₄
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Molecular Weight
314.34
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Cell Permeable
True
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Purity
≥95%
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Solubilities
~10 mg/ml in DMF in 0, ~15 mg/ml in in Ethanol, ~20 mg/ml in in DMSO
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A potent inhibitor of HDAC6
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD27952937
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PubChem CID
71532921
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SMILES
C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO
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InChi
InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
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InChi Key
RFAZNTABYJYOAR-UHFFFAOYSA-N
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MSDS Available
True
