HLCL-61 hydrochloride
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Catalog numberB1209-5
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Price181.5 USD
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Size5 mg
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Alternative_name1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
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DescriptionHLCL-61 is a potent and selective PRMT5 (potent arginine methyltransferase 5) inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. In vitro data shows HLCL-61 effectively inhibits symmetric arginine demethylation of histones H3 and H4 in AML samples. HLCL-61 treatment of cells showed decrease in cell vitality and effective in apoptosis promotion in MV-11 and THP-1 cells after 48 hours.
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CAS Number586395-74-6 (free base).
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Structure AvailableYes
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Salt FormYes
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Molecular FormulaC₂₃H₂₅ClN₂O
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Molecular Weight380.92
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO(>20 mg/ml)
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HandlingProtect from air and light
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Tag LineA selective PRMT5(potent arginine methyltransferase 5) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID17208222
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SMILESCN1C2=C(C=C(C=C2)CNCC3=CC=CC=C3OC)C4=CC=CC=C41.Cl
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InChiInChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
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InChi KeyXYAVCNMZZKTEGR-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolIGHV4-61, SNORA81, IGLV8-61, RNU6-61P, SCARNA2, SH3GLB1
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Short nameHLCL-61 hydrochloride
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Alternative nameHLCL-61 hydrochloride
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Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 4-61
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nucleolar RNA, H/ACA box 81
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-04-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small nucleolar RNAs, H/ACA box
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin lambda variable 8-61
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GenBank acession
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Locus
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Discovery year2000-05-08
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin lambda locus at 22q11.2
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNA, U6 small nuclear 61, pseudogene
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Synonyms gene
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Synonyms gene name
- RNA, U6 small nuclear 61
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Locus
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Discovery year2011-08-08
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Entrez gene record
Gene info
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Identity
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Gene
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Long gene namesmall Cajal body-specific RNA 2
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-03-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Small Cajal body-specific RNAs
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSH3 domain containing GRB2 like, endophilin B1
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Synonyms gene name
- SH3-domain, GRB2-like, endophilin B1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-07-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- N-BAR domain containing
- Protein phosphatase 1 regulatory subunits
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VEGA ID