HDAC1&2 Inhibitor

• Catalog number
  B2930-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  Methyl ester of N-[[4-[[[2-amino-5-(2-thienyl)phenyl]amino]carbonyl]phenyl]methyl]-carbamic acid; methyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate
• Description
  HDAC1&2 inhibitor selectively inhibits Histone deacetylases HDAC1 and HDAC2 with an IC₅₀ of 10 nM and 105 nM for HDAC1 and HDAC2 respectively. It shows a GI₅₀ of 100 nM for HCT-116 cells.
• CAS Number
  1013330-84-1
• Structure Available
  True
• Salt Form
  false
• Molecular Formula
  C₂₀H₁₉N₃O₃S
• Molecular Weight
  381.45
• Cell Permeable
  True
• Purity
  97%
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A selective inhibitor of HDAC1 and 2
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• PubChem CID
  44447194
• PubChem CID Link
• SMILES
  COC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N
• InChi
  InChI=1S/C20H19N3O3S/c1-26-20(25)22-12-13-4-6-14(7-5-13)19(24)23-17-11-15(8-9-16(17)21)18-3-2-10-27-18/h2-11H,12,21H2,1H3,(H,22,25)(H,23,24)
• InChi Key
  XPYFYVJCMDDGKF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  True
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  HDAC1   Inhibitor  
• Gene symbol
  HDAC1
• Short name
  HDAC1 2 Inhibitor
• Alternative name
  histone deacetylase 1&2 suppressor
• Alternative to gene target
  histone deacetylase 1, this GO N-10 and HD1 and RPD3 and RPD3L1, HDAC1 and IDBG-95712 and ENSG00000116478 and 3065, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, HDAC1 and IDBG-644586 and ENSBTAG00000012698 and 404126

Gene info

• Identity
  HGNC:4852
• Gene
  HDAC1
• Long gene name
  histone deacetylase 1
• Synonyms gene
  • RPD3L1
• Synonyms
  • HD1
  • GON-10
  • KDAC1
• GenBank acession
  • D50405
• Locus
  1p35.2-p35.1
• Discovery year
  1996-11-15
• Entrez gene record
  3065
• Pubmed identfication
  • 8602529
• RefSeq identity
  • NM_004964
• Classification
  • NuRD complex subunits
  • Histone deacetylases, class I
  • MiDAC complex subunits
  • EMSY complex
  • SIN3 histone deacetylase complex subunits
• VEGA ID
  OTTHUMG00000007529

Product images

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