Harmine
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Catalog number2561-50
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PricePlease ask
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Size50 mg
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Alternative_name7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
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DescriptionHarmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC₅₀’s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 µM; DYRK4 = 80 µM). Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells(GSLC’s) possibly via inhibition of Akt phosphorylation. Selective competitive and reversible inhibitor of MAO-A (IC₅₀ = 8 µM). Also regulates PPARγ expression and displays antidiabetic activity.
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CAS Number442-51-3
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₁₃H₁₂N₂O
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Molecular Weight212.25
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Cell PermeableYes
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Purity≥98% by titration
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SolubilitiesDMSO (>20 mg/ml)
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HandlingProtect from air and light
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Tag LineA MAO-A and DYRK inhibitor
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Storage Condition-20°C
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Shipping ConditionGel pack
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Shelf Life24 months
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MDL NumberMFCD00004958
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PubChem CID5280953
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SMILESCC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
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InChiInChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
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InChi KeyBXNJHAXVSOCGBA-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameHarmine
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Alternative nameHarmine
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