Halofuginone hydrobromide

Alternative_name

RU-19110, (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
Description

Halofuginone is an an ATP-dependent inhibitor prolyl-tRNA synthetase (Ki of 18.3 nM). Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Blocks expression of MMP2 and inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Also inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.
CAS Number

64924-67-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₆H₁₇BrClN₃O₃.HBr
Molecular Weight

495.59
Cell Permeable

True
Purity

≥98%
Solubilities

>45 mg/ml in DMSO
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A high affinity competitive prolyl-tRNA synthetase inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

400771
PubChem CID Link
SMILES

C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br
InChi

InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/m0./s1
InChi Key

SJUWEPZBTXEUMU-LDXVYITESA-N
Data Sheet Link
MSDS Available

True