GW788388
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Catalog number2820-50
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PricePlease ask
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Size50 mg
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Alternative_name4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide
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DescriptionGW788388 is a potent and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5) (IC₅₀ = 18 nM). Also inhibits TGF-β type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
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CAS Number452342-67-5
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₅H₂₃N₅O₂
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Molecular Weight425.48
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Cell Permeableyes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>40 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent and selective transforming growth factor beta receptor I (TGF-βR1) inhibitor
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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MDL NumberMFCD20527321
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PubChem CID10202642
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SMILESC1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5
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InChiInChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
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InChi KeySAGZIBJAQGBRQA-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameGW788388
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Alternative nameGW788388
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