GSK2578215A

• Catalog number
  2845-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide
• Description
  GSK2578215A is a potent and highly selective leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC₅₀ values are 8.9 and 10.1 nM for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). Shows selectivity for LRRK2 against a panel of 460 other kinases. GSK2578215A displays good blood-brain barrier (BBB) permeability with a high ratio of brain to plasma distribution in mice.
• CAS Number
  1285515-21-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₁₈FN₃O₂
• Molecular Weight
  399.42
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  Apotent and selective LRRK2 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  68107965
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4
• InChi
  InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)
• InChi Key
  WCIGMFCFPXZRMQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  GSK2578215A  
• Short name
  GSK2578215A
• Alternative name
  GSK2578215A

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