GSK-106 hydrochloride

Alternative_name

(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride
Description

GSK-106 is a useful negative control for PAD4 inhibitors (GSK-121 and GSK-484). It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC₅₀s > 100 µM).
CAS Number

1652591-82-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₄H₂₈ClN₅O
Molecular Weight

437.97
Cell Permeable

Yes
Purity

≥98%
Solubilities

DMSO (~30 mg/ml)
Handling

Protect from air and moisture
Tag Line

A useful negative control for PAD4 inhibitors GSK-121 and GSK-484.
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
SMILES

O=C(N1CC(N)CCC1)C2=CC=C3C(N(C)C(C(N4CC)=CC5=C4C=CC=C5)=N3)=C2.[H]Cl
InChi

InChI=1S/C24H27N5O.ClH/c1-3-29-20-9-5-4-7-16(20)13-22(29)23-26-19-11-10-17(14-21(19)27(23)2)24(30)28-12-6-8-18(25)15-28;/h4-5,7,9-11,13-14,18H,3,6,8,12,15,25H2,1-2H3;1H
InChi Key

VRPFLFUQMWOJAT-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:30255
Gene

PRELID1
Long gene name

PRELI domain containing 1
Synonyms
- CGI-106
- PX19
- PRELI
Synonyms name
- protein of relevant evolutionary and lymphoid interest
- px19-like protein
GenBank acession
- BC013748
Locus

5q35.3
Discovery year

2007-02-20
Entrez gene record

27166
Pubmed identfication
- 10784606
- 14640972
RefSeq identity
- NM_013237
Classification
- PRELI domain containing
VEGA ID

OTTHUMG00000130847

Identity

HGNC:8478
Gene

OR8C1P
Long gene name

olfactory receptor family 8 subfamily C member 1 pseudogene
Synonyms gene
- OR8C3P
- OR8C4P
Synonyms gene name
- olfactory receptor, family 8, subfamily C, member 1 pseudogene
Synonyms
GenBank acession
- AF065872
Locus

11q24.2
Discovery year

1998-11-09
Entrez gene record

8580
Pubmed identfication
- 9787077
Classification
- Olfactory receptors, family 8
VEGA ID

OTTHUMG00000154390