Granisetron Hydrochloride

Alternative_name

BRL-43694,1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride,BRL 43694
Description

Granisetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 3.9 nM) with antiemetic activity. It displays selectivity for 5-HT3 over 5-HT4 receptors (Ki = >1,000 nM). Formulations containing granisetron have been used in the prevention of nausea and vomiting associated with chemotherapy.
CAS Number

107007-99-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₈H₂₅ClN₄O
Molecular Weight

348.87
Cell Permeable

1
Purity

≥98%
Solubilities

>10 mg/ml Water
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

An antagonist of the serotonin (5-HT) receptor subtype 5-HT3
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
MDL Number

MFCD01747034
PubChem CID

6918003
PubChem CID Link
SMILES

CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl
InChi

InChI=1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H/t12?,13-,14+;
InChi Key

QYZRTBKYBJRGJB-PCMHIUKPSA-N
Data Sheet Link
MSDS Available

1