Gefitinib

• Catalog number
  1589-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  ZD-1839
• Description
  Gefitinib was found to be a potent inhibitor of EGFR kinase (Ki = 0.40 nM), but much weaker against ErbB-2 kinase (Ki = 870 nM) and ErbB-4 kinase (Ki = 1.1 µM). The IC₅₀ values for Gefitinib to inhibit HT-29 and LoVo cell growth were 23.6 - >100 µM and 7.3 - 48.5 µM, respectively, when the exposure times are from 18 hours to 3 days. The IC₅₀ values of Gefitinib to the breast cancer cell lines BT20, HCC1937, MDA-MB-231, BT474, and SKBR3 are 15.5±1.4, 8.4±1.5, 20.7±1.1, 0.25±0.05, 0.88±0.31 µM, respectively
• CAS Number
  184475-35-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₂H₂₄ClFN₄O₃
• Molecular Weight
  446.9
• Cell Permeable
  Yes
• Purity
  ≥99% by HPLC
• Solubilities
  DMSO (100 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  An EGFR kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  RT
• Shelf Life
  24months
• MDL Number
  MFCD04307832
• PubChem CID
  123631
• PubChem CID Link
• SMILES
  COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
• InChi
  InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10- 7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
• InChi Key
  XGALLCVXEZPNRQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Gefitinib  
• Short name
  Gefitinib
• Alternative name
  Gefitinib

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