FLI-06
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Catalog number2603-25
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PricePlease ask
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Size25 mg
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Alternative_nameCyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
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DescriptionA potent Notch signaling (EC₅₀ = 2.3 µM) as well as the early secretory pathway inhibitor. FLI-06 leads to a disruption of the Golgi by a mechanism different from Brefeldin A (Cat. No. 1560) or other known secretion inhibitors. FLI-06 blocks secretion by inhibiting the recruitment of cargo to ER exit sites, but not the formation of COPII vesicles. FLI-06 transforms the tubular regions of the ER to large sheets, suggesting that regions of high curvature at ER exit sites are essential for the recruitment of cargo.
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CAS Number313967-18-9
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Structure AvailableY
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Salt FormNo
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Molecular FormulaC₂₅H₃₀N₂O₅
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Molecular Weight438.52
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Cell PermeableYes
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Purity>98% by HPLC
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SolubilitiesDMSO (~40 mg/ml) or EtOH (~ 8 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent Notch signaling inhibitor
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Storage Condition-20 ̊C
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Shipping ConditionGel pack
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Shelf Life36 months
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PubChem CID3103157
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SMILESCC1(C)CC(C(C(C2=CC=C([N+]([O-])=O)C=C2)C(C(OC3CCCCC3)=O)=C(C)N4)=C4C1)=O
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InChiInChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
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InChi KeySWWVFYHSSOWZMF-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolFLII, ITPA, HCG4B
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Short nameFLI-06
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Alternative nameFLI-06
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Gene info
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Identity
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Gene
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Long gene nameFLII actin remodeling protein
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Synonyms gene name
- flightless I (Drosophila) homolog
- flightless I homolog (Drosophila)
- flightless I actin binding protein
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-10-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Gelsolin/villins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinosine triphosphatase
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Synonyms gene
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Synonyms gene name
- inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHLA complex group 4B
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Synonyms gene
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Synonyms gene name
- HLA complex group 4 pseudogene 6
- HLA complex group 4B (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-09-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Long non-coding RNAs with non-systematic symbols
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VEGA ID