Fibrinogen (Pg, Fn & vWF depleted), Human Plasma
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Catalog number
7694-250
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Price
Please ask
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Size
250 mg
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Synonyms
Factor 1
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Alternative_names
Factor 1
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Description
A part of the coagulation cascade of proteins.
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Recombinant
No
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Source
Human Plasma
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Biological activity
> 95% clottable by functional assays
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Results
> 95% clottable by functional assays
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Molecular Weight
330.00 kDa
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Storage Temp
-80°C
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Shipping
Dry Ice
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Shelf Life
12 months
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Appearance
Liquid
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Physical form description
In 20 mM Sodium Citrate-HCl pH 7.4.
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Background Information
Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolysis fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Gene target
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Short name
Fibrinogen (Pg, Fn & vWF depleted), Plasma
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Species
Human, Humans
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Alternative name
Fibrinogen (Pg, Fn & von Willebrand factor depleted), H. sapiens Plasma
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Alternative to gene target
von Willebrand factor, F8VWF and VWD, VWF and IDBG-13506 and ENSG00000110799 and 7450, chaperone binding, Extracellular, Vwf and IDBG-189967 and ENSMUSG00000001930 and 22371, VWF and IDBG-640531 and ENSBTAG00000012265 and 280958
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Product images
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