Fexaramine
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Catalog numberB1156-5
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PricePlease ask
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Size5 mg
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Alternative_nameMethyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate
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DescriptionFexaramine is a potent, selective farnesoid X receptor (FXR) agonist (EC₅₀ = 25 nM). It displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. Fexaramine also demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids .
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CAS Number574013-66-4
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₃₂H₃₆N₂O₃
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Molecular Weight498.65
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>40 mg/ml)
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HandlingProtect from air and light
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Tag Linea potent, selective farnesoid X receptor (FXR) agonist
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD09971007
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PubChem CID5326713
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SMILESCN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)C=CC(=O)OC)C(=O)C4CCCCC4
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InChiInChI=1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1-3H3/b21-14+
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InChi KeyVLQTUNDJHLEFEQ-KGENOOAVSA-N
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MSDS AvailableYes
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Gene target
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Short nameFexaramine
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Alternative nameFexaramine
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