Fevipiprant

• Catalog number
  B1588-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid; NVP-QAW039; QAW039
• Description
  Fevipiprant is a prostaglandin D2 (PGD2) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2. It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC₅₀ = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC₅₀s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively). This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.
• CAS Number
  872365-14-5
• Structure Available
  Yes
• Molecular Formula
  C₁₉H₁₇F₃N₂O₄S
• Molecular Weight
  426.41
• Cell Permeable
  yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A prostaglandin D2 (PGD2) receptor antagonist
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  23582412
• PubChem CID Link
• SMILES
  CC1=C(C2=C(N1CC3=C(C=C(C=C3)S(=O)(=O)C)C(F)(F)F)N=CC=C2)CC(=O)O
• InChi
  InChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26)
• InChi Key
  GFPPXZDRVCSVNR-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Fevipiprant  
• Short name
  Fevipiprant
• Alternative name
  Fevipiprant

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