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Alternative_name
3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide; pepcid; N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine; 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide; (1Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide; MK-208; YM-11170
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Description
Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells with an IC₅₀ of 0.6 µM. It suppresses histamine-induced gastric acid secretion in dogs and anesthetized rats with ID₅₀ values of 10 and 400 µg/kg, respectively. It is used to treat ulcers, gastroesophageal reflux disease and heartburn. Famotidine is also being investigated in clinical trials for treatment against COVID-19.
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CAS Number
76824-35-6
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Structure Available
1
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Molecular Formula
C₈H₁₅N₇O₂S₃
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Molecular Weight
337.45
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Cell Permeable
1
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Purity
≥98%
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Solubilities
~30 mg/ml in DMSO
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A competitive inhibitor of histamine H2-receptor
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36months
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MDL Number
MFCD00075320
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PubChem CID
5702160
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SMILES
C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
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InChi
InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)
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InChi Key
XUFQPHANEAPEMJ-UHFFFAOYSA-N
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MSDS Available
1
