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Alternative_name
6,6-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)bis[4-amino- 5-hydroxy-1,3-naphthalenedisulphonic acid] tetrasodium salt
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Description
Evans Blue is a potent inhibitor of the uptake of L-glutamate into synaptic vesicles. Evans blue also inhibits AMPA and kainate receptor-mediated currents with IC₅₀ values of 220 and 150 nM respectively. Also acts as a P2X-selective purinoceptor antagonist.
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CAS Number
314-13-6
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Structure Available
Y
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Salt Form
No
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Molecular Formula
C₃₄H₂₄N₆Na₄O₁₄S₄
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Molecular Weight
960.81
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Cell Permeable
No
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Purity
lmax: 605.0-613.0 nm (H₂O)
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Solubilities
H₂O (~ 10 mg/ml)
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Handling
Protect from light and moisture
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Tag Line
A glutamate uptake inhibitor
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Storage Condition
RT
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD00004021
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PubChem CID
24832074
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SMILES
CC1=C(C=CC(=C1)C2=CC(=C(C=C2)NN=C3C=CC4=C(C3=O)C(=C(C=C4S(=O)(=O)[O-])S(=O)(=O)[O-])N)C)NN=C5C=CC6=C(C5=O)C(=C(C=C6S(=O)(=O)[O-])S(=O)(=O)[O-])N.[Na+].[Na+].[Na+].[Na+]
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InChi
InChI=1S/C34H28N6O14S4.4Na/c1-15-11-17(3-7-21(15)37-39-23-9-5-19-25(55(43,44)45)13-27(57(49,50)51)31(35)29(19)33(23)41)18-4-8-22(16(2)12-18)38-40-24-10-6-20-26(56(46,47)48)14-28(58(52,53)54)32(36)30(20)34(24)42;;;;/h3-14,37-38H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4
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InChi Key
KBNIFDASRCWYGC-UHFFFAOYSA-J
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MSDS Available
Yes
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Properties
Blue has a wavelength of around 480 nm and will make your sample visible. If your sample is too concentrated you can dissolve it in water.
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Conjugation
Blue Substrate