Emricasan

• Catalog number
  B2596-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (S)-3-((S)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid, PF-03491390, IDN-6556
• Description
  Emricasan (PF-03491390) is an irreversible pan-caspase inhibitor. In a mouse model of α-Fas-induced acute liver injury, the orally-administered caspase inhibitor Emricasan was retained in the liver for prolonged periods with a low systemic exposure.
• CAS Number
  254750-02-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₆H₂₇F₄N₃O₇
• Molecular Weight
  569.5
• Cell Permeable
  True
• Purity
  ≥98% by HPLC
• Solubilities
  ~30 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A caspase inhibitor
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  12000240
• PubChem CID Link
• SMILES
  CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C
• InChi
  InChI=1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,36)/t12-,17-/m0/s1
• InChi Key
  SCVHJVCATBPIHN-SJCJKPOMSA-N
• Data Sheet Link
• MSDS Available
  True

• Gene target
  Emricasan  
• Short name
  Emricasan
• Alternative name
  Emricasan

MeSH Data

• Name
  Models, Chemical
• Concept
  Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
• Tree numbers
  • E05.599.495

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