EML-425

Alternative_name

5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Description

EML-425 is a potent, reversible and non-competitive dual CBP and p300 inhibitor (IC₅₀ values are 1.1 and 2.9 μM, respectively). EML425 induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage in human leukemia U937 cells. Cell-permeable.
CAS Number

1675821-32-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₇H₂₄N₂O₄
Molecular Weight

440.49
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>40 mg/ml)
Handling

Protect from air and light
Tag Line

A potent, reversible and non-competitive dual CBP and p300 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
SMILES

O=C1N(CC2=CC=CC=C2)C(/C(C(N1CC3=CC=CC=C3)=O)=C\C4=C(C)C=C(O)C=C4C)=O
InChi

InChI=1S/C27H24N2O4/c1-18-13-22(30)14-19(2)23(18)15-24-25(31)28(16-20-9-5-3-6-10-20)27(33)29(26(24)32)17-21-11-7-4-8-12-21/h3-15,30H,16-17H2,1-2H3
InChi Key

LUGQBJDYUPNAQQ-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes