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Alternative_name
2S,3R,11bS)-2-{[(1R)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline
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Description
A bitter-tasting crystalline alkaloid,derived from ipecac root and used in the treatment of amebiasis and as an emetic.Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures.
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CAS Number
316-42-7
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₉H₄₀N₂O₄·2HCl
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Molecular Weight
553.56
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Cell Permeable
No
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Purity
≥98% by titration
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Solubilities
Water (~ 100 mg/ml)
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Handling
Protect from light and moisture
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Tag Line
A protein synthesis inhibitor
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Storage Condition
+4°C
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Shipping Condition
gel pack
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Shelf Life
48 months
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MDL Number
MFCD00135589
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PubChem CID
3068143
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SMILES
CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.Cl.Cl
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InChi
InChI=1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
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InChi Key
JROGBPMEKVAPEH-GXGBFOEMSA-N
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MSDS Available
Yes
