EI1

• Catalog number
  B2270-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide
• Description
  EI1 is a potent EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC₅₀s = 15 and 13 nM, respectively). It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold selectivity over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression. Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.
• CAS Number
  1418308-27-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₆N₄O₂
• Molecular Weight
  390.5
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~2 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent EZH2 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  72199293
• PubChem CID Link
• SMILES
  CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C
• InChi
  InChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
• InChi Key
  PFHDWRIVDDIFRP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  YES

• Gene target
  EI1  
• Short name
  EI1
• Alternative name
  EI1

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