Doxifluridine

• Catalog number
  B2650-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  Furtulon; 5'-Deoxy-5-fluorouridine; 5-fluoro-5'-deoxyuridine
• Description
  Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.
• CAS Number
  3094-09-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₉H₁₁FN₂O₅
• Molecular Weight
  246.19
• Cell Permeable
  True
• Purity
  ≥98%
• Solubilities
  >10 mg/ml in DMSO, >20 mg/ml in Water
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An oral prodrug of the antineoplastic agent 5-fluorouracil
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD00866530
• PubChem CID
  18343
• PubChem CID Link
• SMILES
  CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O
• InChi
  InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1
• InChi Key
  ZWAOHEXOSAUJHY-ZIYNGMLESA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Doxifluridine  
• Short name
  Doxifluridine
• Alternative name
  Doxifluridine

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