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Alternative_name
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride; Aricept; 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride; E2020
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Description
Donepezil is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 5.7 nM. It produces a significant increase in acetylcholine content in rat cerebral cortex at a dose of 5 mg/kg (po). It is used for treating Alzheimer’s disease.
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CAS Number
120011-70-3
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Structure Available
1
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Salt Form
1
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Molecular Formula
C₂₄H₃₀ClNO₃
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Molecular Weight
415.95
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Cell Permeable
True
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Purity
≥ 97%
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Solubilities
~4 mg/ml in ethanol, ~20 mg/ml in water
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A potent acetylcholinesterase inhibitor
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD00881312
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PubChem CID
5741
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SMILES
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
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InChi
InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
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InChi Key
XWAIAVWHZJNZQQ-UHFFFAOYSA-N
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MSDS Available
1
