Deferasirox

• Catalog number
  B2649-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  ICL670A; 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-benzoic acid
• Description
  Deferasirox is an orally bioavailable tridentate iron chelator. It is selective for iron (Fe(III)) over Cu(II), Zn(II), Mg(II), and Ca(II) but does bind to Al(III). Deferasirox decreases iron levels in iron-loaded rat heart cells in vitro by 45.8 and 55.6% compared to control levels when used at concentrations of 160 and 320 µM, respectively. Deferasirox also inhibits proliferation of SAS human oral squamous carcinoma cells (EC50 = 21 µM), decreases cyclin D1 protein levels, and increases protein levels of N-Myc downregulated gene 1 (NDRG1) and NDRG3.
• CAS Number
  201530-41-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₁₅N₃O₄
• Molecular Weight
  373.36
• Cell Permeable
  True
• Purity
  ≥98%
• Solubilities
  >20 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  Orally active tridentate iron chelator
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD09951804
• PubChem CID
  214348
• PubChem CID Link
• SMILES
  C1=CC=C(C(=C1)C2=NN(C(=N2)C3=CC=CC=C3O)C4=CC=C(C=C4)C(=O)O)O
• InChi
  InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28)
• InChi Key
  BOFQWVMAQOTZIW-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Deferasirox  
• Short name
  Deferasirox
• Alternative name
  Deferasirox

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