Darunavir

• Catalog number
  B3086-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate; Prezista; TMC114; (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate; N-((1S,2R)-3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-benzylpropyl)((1S,2R,5R)-4,6-dioxabicyclo(3.3.0)oct-2-yloxy)carboxamide; UIC-94017
• Description
  Darunavir is an HIV-1 protease inhibitor with an IC₅₀ of 3 nM and cytoxicity of 74.4 μM. It is also also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells. Modelling studies have shown that darunavir can bind to papain like viral protease and may be beneficial in treating SARS-COV-2.
• CAS Number
  206361-99-1
• Structure Available
  1
• Molecular Formula
  C₂₇H₃₇N₃O₇S
• Molecular Weight
  547.7
• Cell Permeable
  True
• Purity
  ≥ 98%
• Solubilities
  ~30 mg/ml in DMF, ~25 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An HIV-1 protease inhibitor
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• MDL Number
  MFCD09260006
• PubChem CID
  213039
• PubChem CID Link
• SMILES
  CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N
• InChi
  InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1
• InChi Key
  CJBJHOAVZSMMDJ-HEXNFIEUSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Darunavir  
• Short name
  Darunavir
• Alternative name
  Darunavir

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