Cystamine dihydrochloride

Alternative_name

2,2'-Disulfanediyldiethanamine dihydrochloride; Ethanamine, 2,2'-dithiobis-, dihydrochloride; Cystamin dihydrochloride; 2-(2-aminoethyldisulfanyl)ethanamine, dihydrochloride; 2,2'-Diaminodiethyl disulfide dihydrochloride
Description

Cystamine is an organic disulfide that inhibits transglutaminase (TGM2) with 44% inhibition observed at a concentration of 2.5 mM. It shows neuroprotective activity in a mouse model of Huntington’s disease. It has an anti-inflammatory effect and reduces severity of colitis in a rat model of inflammatory bowel disease.
CAS Number

56-17-7
Structure Available

True
Salt Form

yes
Molecular Formula

C₄H₁₄Cl₂N₂S₂
Molecular Weight

225.2
Cell Permeable

True
Purity

97%
Solubilities

~5 mg/ml in in DMSO, ~10 mg/ml in PBS, pH 7.2 in 0
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A transglutaminase inhibitor
Storage Condition

-20ºC
Shipping Condition

RT
Shelf Life

36 months
PubChem CID

5941
PubChem CID Link
SMILES

C(CSSCCN)N.Cl.Cl
InChi

InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H
InChi Key

YUFRRMZSSPQMOS-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

1