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Alternative_name
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
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Description
A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents.
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CAS Number
66-81-9
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₅H₂₃NO₄
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Molecular Weight
281.35
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Cell Permeable
Yes
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Purity
>95%
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Handling
Protect from light and moisture
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Tag Line
A protein synthesis inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
6 months
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MDL Number
MFCD00082346
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PubChem CID
6197
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SMILES
CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
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InChi
InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19) 7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
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InChi Key
YPHMISFOHDHNIV-FSZOTQKASA-N
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MSDS Available
Yes