CY-09

Alternative_name

4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid; CY09
Description

CY-09 is a potent and specific NLRP3 inhibitor (Kd = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation.
CAS Number

1073612-91-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₉H₁₂F₃NO₃S₂
Molecular Weight

423.43
Cell Permeable

True
Purity

≥98% by HPLC
Solubilities

>8 mg/ml in DMSO
Handling

Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line

A NLRP3 inhibitor
Storage Condition

-20ºC
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

44561595
PubChem CID Link
SMILES

C1=CC(=CC(=C1)C(F)(F)F)CN2C(=O)C(=CC3=CC=C(C=C3)C(=O)O)SC2=S
InChi

InChI=1S/C19H12F3NO3S2/c20-19(21,22)14-3-1-2-12(8-14)10-23-16(24)15(28-18(23)27)9-11-4-6-13(7-5-11)17(25)26/h1-9H,10H2,(H,25,26)/b15-9-
InChi Key

DJTINRHPPGAPLD-DHDCSXOGSA-N
Data Sheet Link
MSDS Available

True

Identity

HGNC:20900
Gene

TRMT6
Long gene name

tRNA methyltransferase 6 non-catalytic subunit
Synonyms gene name
- tRNA methyltransferase 6 homolog (S. cerevisiae)
- tRNA methyltransferase 6
Synonyms
- GCD10
- MGC5029
- Gcd10p
- CGI-09
GenBank acession
- AK000613
Locus

20p12.3
Discovery year

2007-07-31
Entrez gene record

51605
Pubmed identfication
- 16043508
VEGA ID

OTTHUMG00000031816