Crenolanib
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Catalog number9679-25
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PricePlease ask
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Size25 mg
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Alternative_name1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP-868596; ARO 002
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DescriptionCrenolanib is a highly selective and potent FLT3 tyrosine kinase inhibitor (TKI) with activity against the internal tandem duplication (FLT3/ITD) mutants and the FLT3/D835 point mutants. Also displays inhibitory activity against PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells.
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CAS Number670220-88-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₆H₂₉N₅O₂
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Molecular Weight443.54
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>40 mg/ml)
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HandlingProtect from air and light
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Tag LineA highly selective and potent FLT3 tyrosine kinase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID10366136
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SMILESCC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4
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InChiInChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
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InChi KeyDYNHJHQFHQTFTP-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameCrenolanib
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Alternative nameCrenolanib
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