CP-673451

Alternative_name

1-[2-[5-(2-methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
Description

CP-673451 is a potent inhibitor of PDGFR with IC50 value of 10 nM and 1 nM for PDGFR-α and PDGFR-β, respectively.
CAS Number

343787-29-1
Structure Available

Yes
Salt Form

No
Molecular Formula

C24H27N5O2
Molecular Weight

417.51
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

>20.9 mg/ml in DMSO
Handling

Protect from air and light
Tag Line

A potent inhibitor of PDGFR
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD11100329
PubChem CID

10158940
PubChem CID Link
SMILES

COCCOC1=CC2=C(C=C1)N(C=N2)C3=NC4=C(C=CC=C4N5CCC(CC5)N)C=C3
InChi

1S/C24H27N5O2/c1-30-13-14-31-19-6-7-21-20(15-19)26-16-29(21)23-8-5-17-3-2-4-22(24(17)27-23)28-11-9-18(25)10-12-28/h2-8,15-16,18H,9-14,25H2,1H3
InChi Key

DEEOXSOLTLIWMG-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:1366
Gene

ADAMTS13
Long gene name

ADAM metallopeptidase with thrombospondin type 1 motif 13
Synonyms gene
- C9orf8
Synonyms gene name
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms
- VWFCP
- TTP
- vWF-CP
- FLJ42993
- MGC118899
- MGC118900
- DKFZp434C2322
GenBank acession
- AJ011374
Locus

9q34.2
Discovery year

1999-08-23
Entrez gene record

11093
Pubmed identfication
- 11557746
- 11535495
RefSeq identity
- NM_139025
Classification
- ADAM metallopeptidases with thrombospondin type 1 motif
VEGA ID

OTTHUMG00000020876
Locus Specific Databases
- LRG_544