Coumarin-SAHA

• Catalog number
  B2805-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Coumarin-suberoylanilide hydroxamic acid, N1-Hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)octanediamide
• Description
  Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor. It is a fluorescent probe that competitively binds HDAC. It is a SAHA derivative where the anilino “cap” group is replaced by 7-amino-4-methylcoumarin. The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm, respectively. Fluorescence is quenched by 50% when bound to HDAC8.
• CAS Number
  1260635-77-5
• Structure Available
  True
• Salt Form
  False
• Molecular Formula
  C₁₈H₂₂N₂O₅
• Molecular Weight
  346.38
• Cell Permeable
  True
• Purity
  ≥98%
• Solubilities
  ~5 mg/ml in DMSO and DMF in 0
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  It is a class I and class II histone deacetylase (HDAC) inhibitor
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• PubChem CID
  53393956
• PubChem CID Link
• SMILES
  CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CCCCCCC(=O)NO
• InChi
  InChI=1S/C18H22N2O5/c1-12-10-18(23)25-15-11-13(8-9-14(12)15)19-16(21)6-4-2-3-5-7-17(22)20-24/h8-11,24H,2-7H2,1H3,(H,19,21)(H,20,22)
• InChi Key
  YSRCADVJNRJJAV-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  True

• Gene target
  Coumarin-SAHA  
• Short name
  Coumarin-SAHA
• Alternative name
  Coumarin-SAHA

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