Compound E

• Catalog number
  1949-1000
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
• Description
  Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC₅₀ = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 µM), only weakly affects the presenilase activity.
• CAS Number
  209986-17-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₂₄F₂N₄O₃
• Molecular Weight
  490.5
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 10 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A potent, selective inhibitor of γ-secretase
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11306390
• PubChem CID Link
• SMILES
  CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
• InChi
  InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
• InChi Key
  JNGZXGGOCLZBFB-IVCQMTBJSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Compound  
• Short name
  Compound E
• Alternative name
  Compound E

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