Compound 401

• Catalog number
  1657-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
• Description
  Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC₅₀ = 0.28 µM) that also targets mTOR (IC₅₀ = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in vitro.
• CAS Number
  168425-64-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₆H₁₅N₃O₂
• Molecular Weight
  281.31
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Solubilities
  DMSO (10 mM) or EtOH (5 mM)
• Handling
  Protect from air and light
• Tag Line
  A DNA-PK inhibitor
• Storage Condition
  +4°C
• Shipping Condition
  RT
• Shelf Life
  24 months
• MDL Number
  MFCD10568147
• PubChem CID
  10039361
• PubChem CID Link
• SMILES
  C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2
• InChi
  InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2
• InChi Key
  BVRDQVRQVGRNHG-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Compound   401  
• Short name
  Compound 401
• Alternative name
  Compound 401

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