Cilastatin

• Catalog number
  B2689-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
• Description
  Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin.
• CAS Number
  82009-34-5
• Structure Available
  1
• Molecular Formula
  C₁₆H₂₆N₂O₅S
• Molecular Weight
  358.5
• Cell Permeable
  1
• Purity
  ≥98%
• Solubilities
  ~ 10 mg/ml DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A dipeptidase (dehydropeptidase I inhibitor
• Storage Condition
  -20ºC
• Shelf Life
  36 months
• MDL Number
  MFCD00867379
• PubChem CID
  6435415
• PubChem CID Link
• SMILES
  OC([C@@H](N)CSCCCC/C=C(C(O)=O)\NC([C@@H]1C(C)(C)C1)=O)=O
• InChi
  InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
• InChi Key
  DHSUYTOATWAVLW-WFVMDLQDSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Cilastatin  
• Short name
  Cilastatin
• Alternative name
  Cilastatin

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