CAY10505

• Catalog number
  B2962-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione; 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
• Description
  CAY10505 is a potent inhibitor of phosphoinositide 3-kinase (PI3K), selectively inhibiting the γ isoform with an IC₅₀ of 30 nM. It inhibits the α, β, and δ isoforms of PI3K with IC₅₀ values of 0.94, 20, and 20 μM, respectively. It significantly inhibits the unrelated casein kinase 2 (CK2) with an IC₅₀ of 20 nM. It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages with an IC₅₀ of 228 nM. It improves hypertension-associated vascular endothelial dysfunction in rats.
• CAS Number
  1218777-13-9, 328960-84-5
• Structure Available
  True
• Salt Form
  false
• Molecular Formula
  C₁₄H₈FNO₃S
• Molecular Weight
  289.28
• Cell Permeable
  True
• Purity
  99.8%
• Solubilities
  ~20 mg/ml in DMSO and DMF in 0
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A potent inhibitor of PI3K-γ
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• MDL Number
  MFCD00640727
• PubChem CID
  1204893
• PubChem CID Link
• SMILES
  C1=CC(=CC=C1C2=CC=C(O2)C=C3C(=O)NC(=O)S3)F
• InChi
  InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+
• InChi Key
  UFBTYTGRUBUUIL-KPKJPENVSA-N
• Data Sheet Link
• MSDS Available
  True

• Gene target
  CAY10505  
• Short name
  CAY10505
• Alternative name
  CAY10505

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