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Description
A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G (IC₅₀ = 53 nM and Ki = 63 nM). Acts as a weak inhibitor of chymotrypsin (Ki = 1.5 µM), thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC₅₀ > 100 µM).
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CAS Number
429676-93-7
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₃₆H₃₃N₂O₆P
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Molecular Weight
620.63
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Cell Permeable
No
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Purity
≥98% by HPLC
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Solubilities
DMSO
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Handling
Protect from light and mositure
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Tag Line
A potent Cathepsin G inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
60 months
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MDL Number
MFCD00130750
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PubChem CID
9830518
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SMILES
CN(C1CCN(CC1)C(=O)C2=CC=CC=C2)C(=O)C3=CC4=CC=CC=C4C=C3C(=O)C(C5=CC=CC6= CC=CC=C65)P(=O)(O)O
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InChi
InChI=1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25) 36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42, 43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3, (H2,42,43,44)
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InChi Key
GNOZQRKYZJSIPZ-UHFFFAOYSA-N
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MSDS Available
Yes
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Gene
CTS protease activity also measured by zymograph electrophoresis of Cathepsins. This cathepsin is supplied in 1.
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
