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Alternative_name
(+)-Brusatol; (11β,12α,15β)-13,20-Epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-picras-3-en-21-oic acid methyl ester; NSC 172924; Yatansin
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Description
Brusatol is a quassinoid isolated from the Brucea javanica plant that has recently been shown to inhibit Nrf2 signaling, reduce tumor burden, and ameliorate chemoresistance in both in vitro and in vivo cancer models. Brusatol also inhibits c-Myc expression, and showed that overexpression of c-Myc prevented brusatol-induced degradation of HIF-1α and cancer cell death by increasing mitochondrial ROS production and subsequent ROS-mediated transition of ferrous iron to ferric iron.
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CAS Number
14907-98-3
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₆H₃₂O₁₁
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Molecular Weight
520.53
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Cell Permeable
True
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Purity
≥95% by HPLC
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Solubilities
~5 mg/ml in DMSO
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A unique inhibitor of the Nrf2 pathway
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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MDL Number
MFCD23726642
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PubChem CID
73432
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SMILES
CC1=C(C(=O)CC2(C1CC3C45C2C(C(C(C4C(C(=O)O3)OC(=O)C=C(C)C)(OC5)C(=O)OC)O)O)C)O
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InChi
InChI=1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1
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InChi Key
ZZZYHIMVKOHVIH-VILODJCFSA-N
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MSDS Available
True
