BRD3-BD1 Antibody
-
Catalog number6665-100
-
PricePlease ask
-
Size100 μg
-
-
Antibody TargetBRD3-BD1
-
Target Alternative NameKIAA0043, RING3L
-
Antibody TypePolyclonal
-
Species ReactivitiesHuman
-
Immunogen SequenceRecombinant human BRD3-BD1 (Cat # 7256)
-
AccessionQ15059
-
Gene Id8019
-
AppearanceColorless liquid
-
FormLiquid
-
Concentration0.5 mg/ml
-
Formulation100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
-
PurificationAffinity Purified Antibody
-
ApplicationWestern blot
-
Positive ControlWestern Blot: Recombinant protein
-
Application And UsagesWestern blot: 1-4 µg/ml.
-
DescriptionThe acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people.
-
Storage Condition-20 °C
-
Shipping Conditiongel pack
-
Shelf Life12 months
-
UsageFor Research Use Only! Not to be used in humans.
-
HandlingThe antibody solution should be gently mixed before use.
-
Western Blot VerifiedVerified
-
Immunocytochemistry VerifiedNot Verified
-
Immunofluorescence VerifiedNot Verified
-
Immunoprecipitation VerifiedNot Verified
-
ELISA VerifiedNot Verified
-
ChIP VerifiedNot Verified
-
Dot Blot VerifiedNot Verified
-
Flow Cytometry VerifiedNot Verified
-
PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolBRD3, DEFB1
-
Short nameBRD3-BD1 Antibody
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeRabbit IgG
-
Alternative nameBRD3-BD1 (antibody to-)
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namebromodomain containing 3
-
Synonyms gene name
- bromodomain-containing 3
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year2000-07-25
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Bromodomain containing
- Bromodomain and extra-terminal domain family
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene namedefensin beta 1
-
Synonyms gene name
- defensin, beta 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year1997-05-29
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Defensins, beta
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data