BIX02189

• Catalog number
  2670-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide
• Description
  BIX02189 is a potent MEK5 inhibitor (IC₅₀ = 1.5 nM). Also inhibits ERK5 catalytic activity (IC₅₀ = 59 nM). Does not inhibit closely related kinases MEK1, MEK2, ERK2 and JNK2.
• CAS Number
  1094614-85-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₂₈N₄O₂
• Molecular Weight
  440.54
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent MEK5 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  46931012
• PubChem CID Link
• SMILES
  CN(C)CC1=CC(=CC=C1)NC(=C2C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)C4=CC=CC=C4
• InChi
  InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,28H,17H2,1-4H3,(H,29,32)/b25-24-
• InChi Key
  HOMJAAIVTDVQJA-IZHYLOQSSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BIX02189  
• Short name
  BIX02189
• Alternative name
  BIX02189

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