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Alternative_name
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Didemethoxycurcumin; Curcumin III; Bis(4-hydroxycinnamoyl)methane; Bis(p-hydroxycinnamoyl)methane; Curcuminoid A; Curcumin Lll; DidemethoxycurcumiI; di-p-coumaroylmethane; 1,3-Di(4-hydroxystyryl)propanedial; 1,7-bis(4-hydroxyphenyl)-3-hydroxy-1,3,6-heptatrien-5-one; BDMC
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Description
Bisdemethoxycurcumin is a curcumin analogue with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells and inhibits proliferation of different cell lines at 25 μM. Bisdemethoxycurcumin enhances phagocytosis of amyloid-beta and transcription of MGAT3 and TLR. It down-regulates the transcriptional coactivator p300 and thereby inhibits the Wnt/beta-catenin pathway. It inhibits inducible nitric oxide synthase protein expression and accelerates healing of gastric ulcer in a rat model.
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CAS Number
24939-16-0, 33171-05-0
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Structure Available
True
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Salt Form
false
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Molecular Formula
C₁₉H₁₆O₄
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Molecular Weight
308.33
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Cell Permeable
True
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Purity
>98.0%
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Solubilities
~5 mg/ml in in Ethanol, ~14 mg/ml in DMF in 0, ~10 mg/ml in in DMSO
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A curcumin analogue with anti-inflammatory and anti-proliferative properties
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36months
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PubChem CID
5315472
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SMILES
C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
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InChi
InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
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InChi Key
PREBVFJICNPEKM-YDWXAUTNSA-N
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MSDS Available
True
