BIBW2992 (Tovok)
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Catalog number1616-1
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PricePlease ask
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Size1 mg
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Alternative_nameTovok, Afatinib
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DescriptionBIBW-2992 is a potent irreversible EGFR/HER2 inhibitor. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC₅₀ values of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases and no additional inhibition of other kinases has been observed.
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CAS Number439081-18-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₂₅ClFN₅O₃
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Molecular Weight485.94
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Cell PermeableYes
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Purity≥99%
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SolubilitiesDMSO
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HandlingProtect from air and moisture
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Tag LineAn EGFR/HER2 inhibitor
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Storage Condition-20°C
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Shipping ConditionRT
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Shelf Life24months
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MDL NumberMFCD12407405
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PubChem CID10184653
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SMILESCN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
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InChiInChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34- 16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12, 14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
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InChi KeyULXXDDBFHOBEHA-CWDCEQMOSA-N
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MSDS AvailableYes
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Gene target
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Short nameBIBW2992 (Tovok)
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Alternative nameBIBW2992 (Tovok)
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