BI-7273

Alternative_name

4-(4-((dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
Description

BI-7273 is a potent, selective, and cell-permeable BRD9 bromodomain inhibitor (IC₅₀ ~19 nM). It displays high selectivity against the other bromodomain family members (48 bromodomains) and kinases.
CAS Number

1883429-21-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₂₃N₃O₃
Molecular Weight

353.41
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent, selective, and cell-permeable BRD9 bromodomain inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

118796358
PubChem CID Link
SMILES

CN1C=C(C2=C(C1=O)C=NC=C2)C3=CC(=C(C(=C3)OC)CN(C)C)OC
InChi

InChI=1S/C20H23N3O3/c1-22(2)11-17-18(25-4)8-13(9-19(17)26-5)16-12-23(3)20(24)15-10-21-7-6-14(15)16/h6-10,12H,11H2,1-5H3
InChi Key

RBUYFHLQNPJMQM-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:1664
Gene

SCARB1
Long gene name

scavenger receptor class B member 1
Synonyms gene
- CD36L1
Synonyms gene name
- CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
- scavenger receptor class B, member 1
Synonyms
- SRB1
- CLA-1
- CLA1
- SR-BI
GenBank acession
- Z22555
Locus

12q24.31
Discovery year

1994-09-06
Entrez gene record

949
Pubmed identfication
- 7689561
RefSeq identity
- NM_005505
Classification
- Scavenger receptors
VEGA ID

OTTHUMG00000168544