BI-2536

• Catalog number
  2370-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
• Description
  BI-2536 is a potent, selective inhibitor of polo-like kinase 1 (PLK1) (IC₅₀ = 0.83 nM). It blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC₅₀ of 3.5 nM and 9.0 nM, respectively. BI-2536 potently causes a mitotic arrest and induces apoptosis in human cancer cell lines of diverse tissue origin.
• CAS Number
  755038-02-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₈H₃₉N₇O₃
• Molecular Weight
  521.65
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~20 mg/ml) or Ethanol (~ 100 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A selective polo-like kinase 1 (PLK1) inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD10565924
• PubChem CID
  11364421
• PubChem CID Link
• SMILES
  CCC1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C
• InChi
  InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1
• InChi Key
  XQVVPGYIWAGRNI-JOCHJYFZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BI-2536  
• Gene symbol
  TMBIM6, SCARB1
• Short name
  BI-2536
• Alternative name
  BI-2536

Gene info

• Identity
  HGNC:11723
• Gene
  TMBIM6
• Long gene name
  transmembrane BAX inhibitor motif containing 6
• Synonyms gene
  • TEGT
• Synonyms gene name
  • testis enhanced gene transcript
• Synonyms
  • BI-1
  • BAXI1
• Synonyms name
  • BAX inhibitor 1
• GenBank acession
  • X75861
• Locus
  12q13.12
• Discovery year
  1994-08-30
• Entrez gene record
  7009
• Pubmed identfication
  • 8530040
  • 9660918
• RefSeq identity
  • NM_003217
• Classification
  • Transmembrane BAX inhibitor motif containing
• VEGA ID
  OTTHUMG00000169652

Gene info

• Identity
  HGNC:1664
• Gene
  SCARB1
• Long gene name
  scavenger receptor class B member 1
• Synonyms gene
  • CD36L1
• Synonyms gene name
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
  • scavenger receptor class B, member 1
• Synonyms
  • SRB1
  • CLA-1
  • CLA1
  • SR-BI
• GenBank acession
  • Z22555
• Locus
  12q24.31
• Discovery year
  1994-09-06
• Entrez gene record
  949
• Pubmed identfication
  • 7689561
• RefSeq identity
  • NM_005505
• Classification
  • Scavenger receptors
• VEGA ID
  OTTHUMG00000168544

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