Bedaquiline

• Catalog number
  9598-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolyl)-4-dimethylamino-2-(1-naphthyl)-1-phenyl-butan-2-ol; TMC207
• Description
  Bedaquiline is an anti-tuberculosis drug. Bedaquiline's unique and specific anti-mycobacterial activity derives from inhibition of the proton pump of mycobacterial ATP synthase, which is a critical enzyme in the ATP synthesis of M. tuberculosis. Binding of bedaquiline to the oligomeric and proteolipic subunit-c of mycobacterial ATP synthase leads to inhibition of ATP synthesis, which subsequently results in bacterial death.
• CAS Number
  843663-66-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₂H₃₁BrN₂O₂
• Molecular Weight
  555.5
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  An anti-tuberculosis drug and inhibitor of mycobacterial ATP synthase
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  5388906
• PubChem CID Link
• SMILES
  CN(C)CCC(C1=CC=CC2=CC=CC=C21)(C(C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O
• InChi
  InChI=1S/C32H31BrN2O2/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3/h4-17,20-21,30,36H,18-19H2,1-3H3/t30-,32-/m1/s1
• InChi Key
  QUIJNHUBAXPXFS-XLJNKUFUSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Bedaquiline  
• Short name
  Bedaquiline
• Alternative name
  Bedaquiline

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