BACE2/Asp1 Antibody

• Catalog number
  6102-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  BACE2
• Target Alternative Name
  BACE2, Asp1
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, mouse, rat
• Immunogen Sequence
  A synthetic peptide corresponding to the amino acids 44 to 59 of human BACE2.
• Accession
  Q9Y5Z0
• Gene Id
  25825
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  05 mg/ml
• Formulation
  100 μg (0.5 mg/ml) affinity purified rabbit anti-BACE2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
• Purification
  Affinity chromatography purified via peptide column.
• Application
  Western blot
• Application And Usages
  Western Blot: 1-4 μg/ml. However, the optimal conditions should be determined individually.
• Description
  Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-soμght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', sμggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BACE2/Asp1  
• Gene symbol
  BACE2-IT1, BACE2
• Short name
  BACE2/Asp1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG1
• Alternative name
  BACE2/Asp1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16024
• Gene
  BACE2-IT1
• Long gene name
  BACE2 intronic transcript 1
• Synonyms gene
  • C21orf75
  • NCRNA00228
• Synonyms gene name
  • chromosome 21 open reading frame 75
  • non-protein coding RNA 228
  • BACE2 intronic transcript 1 (non-protein coding)
• Synonyms
  • PRED43
• Locus
  21q22.2
• Discovery year
  2002-11-26
• Entrez gene record
  282569
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000086745

Gene info

• Identity
  HGNC:934
• Gene
  BACE2
• Long gene name
  beta-secretase 2
• Synonyms gene
  • AEPLC
• Synonyms gene name
  • beta-site APP-cleaving enzyme 2
• Synonyms
  • CEAP1
  • DRAP
  • ALP56
• Synonyms name
  • memapsin 1
• GenBank acession
  • AF117892
• Locus
  21q22.2-q22.3
• Discovery year
  2000-05-23
• Entrez gene record
  25825
• Pubmed identfication
  • 10965118
  • 10830953
• Classification
  • Peptidase family A1
• VEGA ID
  OTTHUMG00000086742

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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