Astemizole

• Catalog number
  B3050-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  Hismanal; Histaminos; Paralergin; NSC 329963; 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl]benzimidazol-2-amine; 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole; R 43512
• Description
  Astemizole is a histamine H1-receptor antagonist, with an IC₅₀ of 4 nM. Astemizole also shows potent hERG potassium channel blocking activity with an IC₅₀ of 0.9 nM. Astemizole shows synergistic antiproliferative effects with calcitriol in breast cancer cells and in vivo preclinical models by blocking the EAG1 potassium channel. High throughput screens have shown that astemizole is a promising candidate for stopping replication of SARS-CoV-2 virus.
• CAS Number
  68844-77-9
• Structure Available
  1
• Molecular Formula
  C₂₈H₃₁FN₄O
• Molecular Weight
  458.6
• Cell Permeable
  1
• Purity
  ≥98%
• Solubilities
  ~ 5 mg/ml in ethanol, ~10 mg/ml in DMF, ~20 mg/ml in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A histamine H1-receptor antagonist and hERG potassium channel blocker
• Storage Condition
  -20ºC
• Shipping Condition
  RT
• Shelf Life
  36 months
• MDL Number
  MFCD00153919
• PubChem CID
  2247
• PubChem CID Link
• SMILES
  COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
• InChi
  InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
• InChi Key
  GXDALQBWZGODGZ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  1

• Gene target
  Astemizole  
• Short name
  Astemizole
• Alternative name
  Astemizole

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